Formulation and Evaluation of Buccal Patches of Diclofenac Sodium
نویسنده
چکیده
Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. The backing membrane was prepared by using sodium alginate. The drug containing layer was prepared by using pectin. Different concentrations of plasticizers and permeation enhancers were added. Prepared films were evaluated for surface properties, weight variation, thickness, folding endurance, surface pH, drug content, swelling index and in vitro release. The release kinetics indicated first order release of drug from all formulation.
منابع مشابه
Formulation and physicochemical characterization of buccoadhesive microspheres containing diclofenac sodium.
PURPOSE The present study involves preparation and evaluation of diclofenac buccal-mucoadhesive microparticles for prolongation of buccal residence time. METHODS The microparticles were prepared by modified double-emulsion dehydration method (O1/W/O2) using sodium carboxymethylcellulose (CMC-Na) as mucoadhesive polymer. Calcium chloride was used as a cross-linking agent. Buccal-mucoadhesive m...
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Diclofenac sodium as ophthalmic dosage form is used in patients treatment of eye pain, swelling and redness recovering from cataract surgery but it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. Drug ...
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